Sally N Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn Meters Rexrode, Connection ranging from intakes away from magnesium, potassium, and you may calcium supplements and you may danger of coronary arrest: 2 cohorts people people and you can up-to-date meta-analyses, The new Western Record off Health-related Diet, Regularity 101, Point six, , Users 1269–1277,
Abstract
Background: Potential study toward family members from magnesium, potassium, and you will calcium intakes which have stroke risk is actually inconsistent, and our very own knowledge, the outcome away from a combined nutrient eating plan rating has not been tested.
Objective: I checked out contacts anywhere between consumption regarding magnesium, potassium, and calcium and you can risk of incident heart attack from inside the 86,149 feamales in new Nurses’ Health Study (NHS) We and 94 dating site Gamer singles only,715 women in brand new NHS II.
Design: Contained in this prospective cohort data, we computed Time of coronary arrest of the quintiles away from consumption for each and every mineral as well as for a mixed diet score of all of the step three nutrition by using multivariate Cox proportional danger patterns. While doing so, we current meta-analyses towards the fat reduction consumption of them nutrition and likelihood of coronary attack.
Results: Through the follow-upwards (30 y about NHS I; twenty-two y in the NHS II) a total of 3780 experience coronary attack cases was in fact recorded. Pooled multivariate RRs off complete heart attack for women from the large compared to the lowest quintiles was basically 0.87 (95% CI: 0.78, 0.97) to own total magnesium, 0.89 (95% CI: 0.80, 0.99) to possess full potassium, and 0.97 (95% CI: 0.87, step 1.09) having total calcium supplements consumption. Pooled RRs for ladies throughout the highest compared to a low quintiles of a mixed mineral eating plan score was 0.72 (95% CI: 0.65, 0.81) having total coronary arrest, 0.78 (95% CI: 0.66, 0.92) for ischemic coronary arrest, and you may 0.80 (95% CI: 0.61, 1.04) for hemorrhagic stroke. In the current meta-analyses of the many possible degree so far, the latest combined RR away from total heart attack are 0.87 (95% CI: 0.83, 0.92) to own an one hundred-mg/d rise in magnesium consumption, 0.91 (95% CI: 0.88, 0.94) having a great a thousand-mg/d escalation in potassium intake, and you may 0.98 (95% CI: 0.94, step 1.02) to possess a 300-mg/d escalation in calcium supplements consumption.
Conclusions: A mixed nutrient diet plan get was inversely associated with threat of coronary attack. High intakes out of magnesium and potassium not calcium supplements was basically including significantly from the shorter risk of stroke in women.
Inclusion
Magnesium is a vital nutrient and you may cofactor to possess >300 enzymatic reactions within the body ( 1). Magnesium ‘s the next very-numerous intracellular cation alongside potassium ( 2). Calcium is among the most-plentiful nutrient in the body. Particularly magnesium and you may potassium, calcium supplements try critically involved in aerobic services ( 3). Highest fat reduction intakes of any ones minerals were reported in order to all the way down risk of hypertension ( 4– 7), which is the principal convertible coronary attack exposure basis. not, not all possible training checked out this new family relations ranging from fat reduction and extra consumption of these vitamins and risk of coronary attack in females, and you can results was inconsistent. Prospective knowledge in European countries shown magnesium intake, but not consumption away from potassium or calcium supplements, was rather regarding the less chance of stroke ( eight, 8). In the us, consumption from potassium and you will magnesium, but not out of calcium, was basically associated with shorter heart attack chance during the males ( 9), while calcium and you will potassium consumption, yet not magnesium consumption, have been regarding the less coronary arrest chance in women ( 10). Also, one to research shown no complete organization anywhere between some of these minerals and you will threat of heart attack ( 11).
The potential observational knowledge that have been held failed to include follow-right up beyond 15 y and had a comparatively few incident coronary arrest occurrences, and in most training, new separate effect of for each nutrient intake out-of tablets and heart attack versions wasn’t checked out. In this article, you can expect research towards relationship of any nutrient intake off dieting and medications which have risk of complete, ischemic, and you can hemorrhagic experience shots. At the same time, we hypothesized that a combined eating plan rating of all of the step 3 nutrients is of the smaller heart attack chance mainly because nutrients exists together with her within the foods, and you will intakes is actually highly correlated. I managed these types of tries during the Us women that was basically adopted prospectively in the 2 higher cohorts the brand new Nurses’ Health Investigation (NHS) 5 We and you will II.